- In October 1968, Aristotle Onassis attempted to purchase the painting as a wedding present for his fiancée, Jacqueline Kennedy.
- The French once loaned this priceless treasure to the United States for display at the National Gallery of Art in Washington, D.C.
- Pablo Picasso was arrested in connection with stealing it in 1911.
- Hedda Hopper portrayed the woman on whom the portrait was based in a 1926 Hollywood film.
Hedda Hopper did in fact portray Mona Lisa in a 1926 silent film that, but for a tiny fragment, is now lost. The powerful Hollywood gossip columnist first came to Hollywood to act, but her performances lacked the sparkle of her reporting. Even in those early days, she was too much of a harridan to convincingly play an ingenue, and the only such part ever offered her was Mona Lisa.